Objective to ensure the safety of disposable sterile medical supplies for patients by taking effective management measures. Methods four level management mode was adopted, including bidding procurement, certificate review, warehousing acceptance, pre use verification, and quarterly spot check on the in use products of each department. Results no unqualified products were found in the hospital for many years, Conclusion the management of disposable sterile medical supplies is a closely related process. Good management of disposable sterile medical supplies can reduce the risk factors of nosocomial infection